Search of MicroRNAs Regulating the Receptor Status of Breast Cancer In Silico and Experimental Confirmation of Their Expression in Tumors.

MicroRNA whose expression depends on the receptor status of breast cancer were selected using bioinformatic analysis. The expression of 9 microRNAs (16, 17, 21, 27, 125, 146, 155, 200a, and 221) was analyzed in 76 samples of breast cancer with various receptor phenotypes. The expression of microRNAs 155, 27, and 200a did not differ in various types of breast cancer. The data on positive correlation between the expression of microRNA-21 and microRNA-221 and negative receptor status of the tumor were confirmed. The expression of the tumor suppressing microRNA-125b decreased in samples of breast cancer expressing HER2 and ER and in triple negative breast cancer, which characterizes it as a universal marker of breast cancer. An increase in the expression of microRNA-16 was shown in samples of breast cancer expressing HER2 and ER. The expression of microRNA-17 decreased in triple negative breast cancer and increased in ER+, PR+, and HER+ types of breast cancer. MicroRNAs 16, 17, 21, 125b, 146b, and 221 can be promising markers for differential diagnostics of various phenotypes of breast cancer.

[About experience of medidine of the Navy during the Great Patriotic War].

The article is devoted activity of the Medical Service of the Navy during the Great Patriotic War. During the war the Navy has performed as an integral part of the Armed Forces, played a major role in the defensive and offensive operations. From the first days of the war medical service fleet faced extreme difficulties, to demand from the medical staff of hard work. During the war many problems of medical support for combat operations of the Navy were successfully solved. It was also important to solve complex problems in organizing and conducting medical evacuations via sea. A great attention during: the war was played to the search for optimal system medical evacuation support of naval forces.

[The experience in organizing the medical support of allied convoys during the Great Patriotic War on the northern maritime theater].

The medical support of allied convoys during the Great Patriotic War had a number of features. The Intensity of power of the fighting, the meteorological conditions, the composition of convoy's forces, the kind of enemy's weapon - had a significant impact on the structure of losses in personnel. The main type of medical care on the ships of 2-3rd rank was predoctor care. On the large and small antisubmarine ships and torpedo boats - it was first aid. The factor which has been affecting the amount of assistance - was a one-time inflow of a significant number of victims. Medical-evacuation provision of the convoys was carried out by the ships medical service without the use of amplification and sanitary ships. The most part of the wounded were taken to the coastal fleet hospitals later than 12 hours after the wound. The war experience has shown that in the distant convoys qualified surgical assistance may be provided in case of organizing it in this convoy and in case of using high-speed vehicles.

[1st Naval Hospital during the Great Patriotic War].

In the article about The First Naval Hospital, that became famous during the Great Patriotic War, the authors present the facts of the heroic work of the hospital and its staff under the hardest conditions of the Siege of Leningrad, in an atmosphere of constant shelling, its productive clinical and scientfic work during the war years (1941-1945). As a material for the preparation of this article were used documents of the Military-Medical Museum, factual information about the history of the hospital published in various sources.

[Shestov V I--the founder of the Department of Organisation and tactics of the naval medical services].

Vasilii Ivanovich Shestov during the Great Patriotic War performed various tasks concerning the organization of medical support in the Leningrad naval base, consulted on an issue of production and use of hospital and medical transport ships, worked on the organization of medical support in Schliessburg and etc. Shestov performed a considerable amount of research and methodological works concerning the establishment of the discipline "Organisation of naval medical support". He is considered as one of the founders of the theory of naval medical evacuation support.

[Directions of interdepartmental interaction in case of delivery of health care for injured in emergency situations in stationing sites of navy].

In points basing of navy will remain probability of emergence of emergency situations which is connected with existence of the enterprises of the industry and objects of navy. As a result of emergency situations in places of basing of navy discrepancy of prospective sanitary losses to possibilities of forces and means of a health service of fleet that demands interaction with health services of other ministries and departments is probable. Criterion of need of interaction is the ratio of quantity struck and possibilities of a health service of navy. Plans of interaction of a health service of fleet with medical institutions of other departments should provide options of use of available forces and means of medical institutions in garrisons for joint assistance struck in an emergency situation. The questions solved during interaction should become: radiation, chemical, biological survey; allocation of forces and means for rendering of medical care; use of sanitary transport; organization of sanitary processing, etc.

[Expert assessment of commands of naval medical service, incorporated in Service for Disaster Medicine].

Expert assessment of possibilities of naval medical service for delivery of assistance in emergency situations in deployment areas is performed. It is noted that the main menaces are radiation, chemical accidents, and explosiveness of objects. Inconsistency between supposed losses and possibilities of naval medical service is probable in case of emergency. This inconsistency requires improvement of interaction with medical services of other ministries, drill of coordinative actions of naval medical commands with other commands of other ministries in organizational frames of united Service for Disaster Medicine.